Imaging and Understanding BOS in Lung Transplantation
This study is a prospective, non-randomized, longitudinal, observational study that will recruit about 5 lung transplant patients per year for 3 years.
This study is a prospective, non-randomized, longitudinal, observational study that will recruit about 5 lung transplant patients per year for 3 years. We will follow these patients at 6 months and 1 year with Hyperpolarized Helium-3 Magnetic Resonance Imaging and image guided bronchial biopsies to detect early BOS and to better understand BO disease progression. The biopsies will provide future research for rapid determination of cellular and molecular mechanisms that lead to BOS and to facilitate identification and validation of translatable pharmaceutical targets.
|Gender||Minimum Age||Maximum Age||Healthy Volunteers?|
|Both||1 Year||25 Years||False|
- Lung Transplantation within the last 10 years or being assessed for possible lung transplantation.
- Male or female
- 0 to 25 years of age.
- Standard MRI exclusion criteria as set forth by the CCHMC Division of Radiology
- Inability to perform 10 second breath hold for 3He MRI scan
- Bleeding disorders
Interventions & Outcomes
Study Interventions & Types
Hyperpolarized Helium-3 MRI - Subjects will inhale Hyperpolarized Helium-3 gas during the MRI. This gas enhances images and the data collected will be used to determine if it can be used to detect BOS earlier than current standard of care.
Timeframe: 3 years
Measure: Analysis of MRI imaging to detect BOS compared to biopsy
Description: Analysis of MRI imaging to detect BOS compared to biopsy
Safety Issue? No
Research Study Facility Map
Facility is not yet recruiting
Clinical Research Study Facility Locations
Children's Hospital Medical Center
Cincinnati, Ohio 45229 United States