Use of Hyperpolarized 129Xe MR Lung Imaging in Adults for Calibration

Condition(s): Respiratory Disorders
NCTId: NCT02316379

Official Title

Use of Hyperpolarized 129Xe MR Lung Imaging in Adults for Calibration

Summary

The goal of this study is to evaluate the usefulness of hyperpolarized (HP) 129Xe (xenon) gas MRI for regional assessment of lung function in a normal population of adults for the purposes of obtaining optimal images through MRI.

Detailed Description

Hyperpolarized 129Xe will be produced, by trained staff, using a polarizer housed at Cincinnati Children's Hospital Medical Center. Individual imaging sessions will be done on a single day and will involve administration of (maximum) 1 liter doses for up to four MRI scans. Subject will inhale hyperpolarized xenon gas and hold breath for up to 16 seconds during the MRI scans. In addition to 129 Xe MRI, a series of anatomical conventional proton MR images may also be collected. Follow up will be done one day and 30 days from the MRI date.

Eligibility

Eligibility Criteria

Gender Minimum Age Maximum Age Healthy Volunteers?
Both 18 Years N/A True

Inclusion Criteria:

- Adults ages 18 years and older

- Participant must be able to hold their breath for up to 16 seconds

Exclusion Criteria:

- History of heart defect

- Pregnancy or positive pregnancy test

- History of uncontrolled asthma defined for this study as requiring use of rescue inhaler ≥ 2 times in past month.

- Symptoms of respiratory infection (loose or productive cough or wheeze), chest tightness, or sinus infection within past week.

- Baseline oximetry at MRI visit of less than 95% on room air or less than 95% on a previously prescribed dosage of oxygen delivered by nasal cannula.

- Participant is claustrophobic and unable to tolerate the imaging.

- Standard MRI exclusions (metal, implants).

Interventions & Outcomes

Study Interventions & Types

Drug Intervention(s)

Hyperpolarized 129 Xenon - During the scans, subject will inhale hyperpolarized Xenon gas for up to 16 seconds per scan, for up to 4 separate MR scans

Device Intervention(s)

MRI

Study Outcomes

Primary Outcome(s)

Timeframe: Day 1
Measure: Correlation of ventilated volume predictions obtained with 129Xe MRI vs. 1H MRI
Description: quantify the measurement agreement between the ventilated volume of healthy lungs predicted via 129 Xe MRI and the ventilated volume of the pleural cavity predicted via proton MRI
Safety Issue? No

Facility Locations

Research Study Facility Map

Map of facility locations for this research study.

Facility is recruiting
Facility is not yet recruiting
Unknown status

Clinical Research Study Facility Locations

Not yet recruiting

Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio 45229 United States

Related Keywords & Studies

Conditions and Diseases with Related Research Studies

  1. Respiratory Disorders

Other Related Condition Keywords

  1. Respiration Disorders
  2. Respiratory Tract Diseases

Related Intervention Keywords

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